{"entity":{"id":"nct03608631","kind":"trial","name":"iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation","aka":[],"tldr":"A phase 1/2 trial in pancreatic cancer, run by M.D. Anderson Cancer Center, now recruiting.","summary":"iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation is a phase 1/2, interventional study registered as NCT03608631 by M.D. Anderson Cancer Center, with a registry enrolment figure of 28 participants, started 2021-01-27 and due to reach its primary completion in 2027-04-30. Interventions recorded: Mesenchymal Stromal Cells-derived Exosomes with KRAS G12D siRNA. Conditions listed: KRAS NP_004976.2:p.G12D; Metastatic Pancreatic Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Stage IV Pancreatic Cancer AJCC v8. Primary outcome: Maximum Tolerated Dose Determined by Dose Limiting Toxicity; Minimal residual disease rate in high-risk patients; Overall survival (OS). Pancreatic eligibility wording from the registry: \"* Patients with histologically confirmed metastatic pancreatic ductal adenocarcinoma harboring KrasG12D mutation\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT03608631","url":"https://clinicaltrials.gov/study/NCT03608631"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["metastatic-pdac"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03608631","phase":"1/2","setting":"Phase I Study of Mesenchymal Stromal Cells-Derived Exosomes With KrasG12D siRNA for Metastatic Pancreas Cancer Patients Harboring KrasG12D Mutation","sponsor":"M.D. Anderson Cancer Center","enrolled":28,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03608631/","neighbours":{"cancer":[{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}