{"entity":{"id":"nct03731260","kind":"trial","name":"(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo ","aka":[],"tldr":"A phase 2 trial of Avapritinib in systemic mastocytosis, run by Blueprint Medicines Corporation, active and no longer recruiting.","summary":"(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis is a phase 2 interventional study registered as NCT03731260 by Blueprint Medicines Corporation, with 251 participants enrolled, started 2019-04-16 and due to reach its primary completion in 2027-06-23. Interventions recorded: Avapritinib, Placebo. Conditions listed: Indolent Systemic Mastocytosis. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT03731260","url":"https://clinicaltrials.gov/study/NCT03731260"}],"tags":["ctgov-ingest"],"related":[],"cancers":["systemic-mastocytosis"],"sections":[],"technologies":[],"targets":[],"drugs":["avapritinib"],"companies":["sanofi"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT03731260","phase":"2","setting":"A 3-Part, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study to Evaluate Safety and Efficacy of Avapritinib (BLU-285), a Selective KIT Mutation-Targeted Tyrosine Kinase Inhibitor, in Indolent and Smoldering Systemic Mastocytosis With Symptoms Inadequately Controlled With Standard Therapy","sponsor":"Blueprint Medicines Corporation","enrolled":251,"outcomes":[]},"route":"/trials/nct03731260/","neighbours":{"cancer":[{"id":"systemic-mastocytosis","kind":"cancer","name":"Systemic mastocytosis","route":"/cancers/systemic-mastocytosis/"}],"drug":[{"id":"avapritinib","kind":"drug","name":"Avapritinib","route":"/drugs/avapritinib/"}],"company":[{"id":"sanofi","kind":"company","name":"Sanofi","route":"/companies/sanofi/"}]}}