{"entity":{"id":"nct03744468","kind":"trial","name":"Study of Surzebiclimab (BGB-A425) and Alcestobart (LBL-007) in Combination With Tislelizumab in Advanced Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of Alcestobart run by BeiGene, completed.","summary":"Study of Surzebiclimab (BGB-A425) and Alcestobart (LBL-007) in Combination With Tislelizumab in Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT03744468 by BeiGene, with 147 participants enrolled, started 2018-11-13. Conditions recorded: Locally Advanced or Metastatic Solid Tumors for Phase 1, Dose Escalation and Phase 2 Safety Lead-in, HNSCC for Phase 2 Dose Expansion and NSCLC for Phase 2 Dose Expansion. Interventions recorded: Surzebiclimab, Tislelizumab and Alcestobart.","status":"completed","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT03744468","url":"https://clinicaltrials.gov/study/NCT03744468"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer","head-and-neck","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":["alcestobart"],"companies":["nanjing-leads-biolabs"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03744468","phase":"1/2","setting":"Phase 1-2 Study Investigating Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of Various Combinations of BGB-A425 and LBL-007 With Tislelizumab in Patients With Advanced Solid Tumors","sponsor":"BeiGene","enrolled":147,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03744468/","neighbours":{"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"alcestobart","kind":"drug","name":"Alcestobart","route":"/drugs/alcestobart/"}],"company":[{"id":"nanjing-leads-biolabs","kind":"company","name":"Nanjing Leads Biolabs","route":"/companies/nanjing-leads-biolabs/"}]}}