{"entity":{"id":"nct03896568","kind":"trial","name":"MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma","aka":[],"tldr":"A phase 1 trial of DNX-2401 run by M.D. Anderson Cancer Center, now recruiting.","summary":"MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma is a phase 1 interventional study registered as NCT03896568 by M.D. Anderson Cancer Center, with 36 participants planned, started 2019-02-12. Conditions recorded: IDH1 wt Allele, Recurrent Anaplastic Astrocytoma, Recurrent Glioblastoma, Recurrent Gliosarcoma and Recurrent Malignant Glioma. Interventions recorded: Oncolytic Adenovirus Ad5-DNX-2401 and Therapeutic Conventional Surgery.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT03896568","url":"https://clinicaltrials.gov/study/NCT03896568"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["brain-tumours","glioblastoma","metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["dnx-2401"],"companies":["dnatrix"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03896568","phase":"1","setting":"Phase I Clinical Trial of Allogeneic Bone Marrow Human Mesenchymal Stem Cells Loaded With A Tumor Selective Oncolytic Adenovirus, DNX-2401, Administered Via Intra-Arterial Injection in Patients With Recurrent High-Grade Glioma","sponsor":"M.D. Anderson Cancer Center","enrolled":36,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03896568/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"dnx-2401","kind":"drug","name":"DNX-2401","route":"/drugs/dnx-2401/"}],"company":[{"id":"dnatrix","kind":"company","name":"DNAtrix","route":"/companies/dnatrix/"}]}}