{"entity":{"id":"nct03919461","kind":"trial","name":"Colorectal Metastasis Prevention International Trial 2","aka":["COMPIT-2"],"tldr":"A phase 2 trial of propranolol (Hemangeol) in colorectal cancer, run by Assaf-Harofeh Medical Center, now recruiting.","summary":"Colorectal Metastasis Prevention International Trial 2 is a phase 2, randomised interventional study registered as NCT03919461 by Assaf-Harofeh Medical Center, with a registry enrolment figure of 200 participants, started 2019-02-28 and due to reach its primary completion in 2027-02-28. Interventions recorded: Propranolol and etodolac; Placebo. Conditions listed: Colorectal Neoplasms. Primary outcome: 5-year disease-free-survival; Biomarkers in extracted tumor tissue samples assessing pro- and anti-metastatic processes; Biomarkers in blood samples assessing pro- and anti-metastatic processes. Colorectal eligibility wording from the registry: \"Patients planned for surgery for primary resection of colon or rectal cancer with curative intent\". Sites: Israel. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT03919461","url":"https://clinicaltrials.gov/study/NCT03919461"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["propranolol-hemangeol"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03919461","phase":"2","setting":"Perioperative Use of a β-adrenergic Blocker, Propranolol, and a COX2 Inhibitor, Etodolac, in Patients Undergoing Resection With Curative Intent for Primary Colon and Rectal Cancer: Effect on Tumor Recurrence and Survival","sponsor":"Assaf-Harofeh Medical Center","enrolled":200,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03919461/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"drug":[{"id":"propranolol-hemangeol","kind":"drug","name":"Propranolol (Hemangeol)","route":"/drugs/propranolol-hemangeol/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}