{"entity":{"id":"nct03926338","kind":"trial","name":"Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer","aka":["PICC"],"tldr":"A phase 2 trial of toripalimab in colorectal cancer, run by Sun Yat-sen University, now recruiting.","summary":"Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer is a phase 2, randomised interventional study registered as NCT03926338 by Sun Yat-sen University, with a registry enrolment figure of 270 participants, started 2019-05-10 and due to reach its primary completion in 2027-04-01. Interventions recorded: Neoadjuvant toripalimab plus celecoxib for 6 cycles; Neoadjuvant toripalimab monotherapy for 6 cycles; Neoadjuvant toripalimab plus celecoxib for 12 cycles; Neoadjuvant toripalimab monotherapy for 12 cycles; Toripalimab plus celecoxib as neoadjuvant or definitive therapy. Conditions listed: Colorectal Cancer; Mismatch Repair-deficient (dMMR); Microsatellite Instability-high (MSI-H); Neoadjuvant Therapy. Primary outcome: Pathological complete response (pCR) rates (PICC-1 and PICC-2 cohorts); Event-free survival (EFS) (PICC-3 cohort). Colorectal eligibility wording from the registry: \"Histological or cytological documentation of adenocarcinoma of the colon or rectum\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT03926338","url":"https://clinicaltrials.gov/study/NCT03926338"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","msi-high-colorectal"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["toripalimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03926338","phase":"2","setting":"Neoadjuvant PD-1 Blockade by Toripalimab With or Without Celecoxib in Mismatch-repair Deficient or Microsatellite Instability-high Locally Advanced Colorectal Cancer (PICC)","sponsor":"Sun Yat-sen University","enrolled":270,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03926338/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"toripalimab","kind":"drug","name":"Toripalimab","route":"/drugs/toripalimab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}