{"entity":{"id":"nct03975049","kind":"trial","name":"Triplet Combination or Doublet Regimen Versus Chemoradiation as Neoadjuvant Therapy for Locally Advanced Rectal Cancer","aka":[],"tldr":"A phase 3 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, not yet recruiting.","summary":"Triplet Combination or Doublet Regimen Versus Chemoradiation as Neoadjuvant Therapy for Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT03975049 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 933 participants, started 2019-08 and due to reach its primary completion in 2024-07. Interventions recorded: Chemoradiation; FOLFOXIRI Protocol; Folfox Protocol. Conditions listed: Rectal Cancer; Chemotherapy Effect. Primary outcome: Disease-free survival. Colorectal eligibility wording from the registry: \"* 2）Histological diagnosis of rectal adenocarcinoma;\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT03975049","url":"https://clinicaltrials.gov/study/NCT03975049"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03975049","phase":"3","setting":"A Prospectively Randomized Phase III Trial Comparing Short-term mFOLFOXIRI, Long-term mFOLFOX6 and Traditional Chemoradiation as Preoperative Neoadjuvant Therapy for Locally Advanced Rectal Cancer","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","enrolled":933,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03975049/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}