{"entity":{"id":"nct03980041","kind":"trial","name":"Study to Evaluate the Efficacy/Safety of IPI-549 in Combination With Nivolumab in Patients With Advanced Urothelial Carcinoma (MARIO-275)","aka":[],"tldr":"A phase 2 trial of Eganelisib run by Infinity Pharmaceuticals, Inc., completed.","summary":"Study to Evaluate the Efficacy/Safety of IPI-549 in Combination With Nivolumab in Patients With Advanced Urothelial Carcinoma (MARIO-275) is a phase 2 interventional study registered as NCT03980041 by Infinity Pharmaceuticals, Inc., with 49 participants enrolled, started 2019-09-25. Conditions recorded: Bladder Cancer, Urothelial Carcinoma, Solid Tumor and Advanced Cancer. Interventions recorded: IPI-549 (eganelisib), Nivolumab and Placebos.","status":"completed","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT03980041","url":"https://clinicaltrials.gov/study/NCT03980041"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["urothelial","metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["eganelisib"],"companies":["stelexis-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03980041","phase":"2","setting":"A Phase 2, Multicenter, Randomized, Double-Blind, Active-Control Study to Evaluate the Efficacy and Safety of Nivolumab Administered in Combination With IPI-549 Compared to Nivolumab Monotherapy in the Treatment of Patients With Immune Therapy-Naïve, Advanced Urothelial Carcinoma","sponsor":"Infinity Pharmaceuticals, Inc.","enrolled":49,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03980041/","neighbours":{"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"eganelisib","kind":"drug","name":"Eganelisib","route":"/drugs/eganelisib/"}],"company":[{"id":"stelexis-biosciences","kind":"company","name":"Stelexis BioSciences","route":"/companies/stelexis-biosciences/"}]}}