{"entity":{"id":"nct04172532","kind":"trial","name":"Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer","aka":[],"tldr":"A phase 1/2 trial in pancreatic cancer, run by National Cancer Institute (NCI), now recruiting.","summary":"Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer is a phase 1/2, randomised interventional study registered as NCT04172532 by National Cancer Institute (NCI), with a registry enrolment figure of 92 participants, started 2021-01-11 and due to reach its primary completion in 2027-08-01. Interventions recorded: Biopsy Procedure; Biospecimen Collection; Computed Tomography; Hypofractionated Radiation Therapy; Magnetic Resonance Imaging; Peposertib; Placebo Administration. Conditions listed: Locally Advanced Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer AJCC v8. Primary outcome: Maximum tolerated dose (Phase I); Recommended phase 2 dose (Phase I); Progression-free survival rate (Phase II). Pancreatic eligibility wording from the registry: \"* Patients must have pathologically confirmed pancreatic adenocarcinoma\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT04172532","url":"https://clinicaltrials.gov/study/NCT04172532"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["locally-advanced-pdac"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04172532","phase":"1/2","setting":"A Phase 1/2 Study of M3814 (Peposertib) in Combination With Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma","sponsor":"National Cancer Institute (NCI)","enrolled":92,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04172532/","neighbours":{"cancer":[{"id":"locally-advanced-pdac","kind":"cancer","name":"Locally advanced unresectable pancreatic ductal adenocarcinoma","route":"/cancers/locally-advanced-pdac/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}