{"entity":{"id":"nct04180371","kind":"trial","name":"Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression","aka":[],"tldr":"A phase 1/2 trial of Nivolumab in ovarian cancer and non-small-cell lung cancer, run by BicycleTx Limited, active and no longer recruiting.","summary":"Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression is a phase 1/2 interventional study registered as NCT04180371 by BicycleTx Limited, with 288 participants planned, started 2019-11-07 and due to reach its primary completion in 2026-07-31. Interventions recorded: BT5528, Nivolumab. Conditions listed: Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04180371","url":"https://clinicaltrials.gov/study/NCT04180371"}],"tags":["ctgov-ingest"],"related":[],"cancers":["ovarian","nsclc","sclc"],"sections":[],"technologies":[],"targets":[],"drugs":["nivolumab"],"companies":["bicycle-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT04180371","phase":"1/2","setting":"Phase I/II Study of the Safety, Pharmacokinetics, and Preliminary Clinical Activity of BT5528 in Patients With Advanced Malignancies Associated With EphA2 Expression","sponsor":"BicycleTx Limited","enrolled":288,"outcomes":[]},"route":"/trials/nct04180371/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"nivolumab","kind":"drug","name":"Nivolumab","route":"/drugs/nivolumab/"}],"company":[{"id":"bicycle-therapeutics","kind":"company","name":"Bicycle Therapeutics","route":"/companies/bicycle-therapeutics/"}]}}