{"entity":{"id":"nct04215731","kind":"trial","name":"Neoadjuvant mFOLFOXIRI Plus Bevacizumab in Patients With High-Risk Locally Advanced Rectal Cancer","aka":["FOBEAR"],"tldr":"A phase 3 trial in colorectal cancer, run by Yanhong Deng, now recruiting.","summary":"Neoadjuvant mFOLFOXIRI Plus Bevacizumab in Patients With High-Risk Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT04215731 by Yanhong Deng, with a registry enrolment figure of 582 participants, started 2020-03-27 and due to reach its primary completion in 2026-09-01. Interventions recorded: Neoadjuvant chemotherapy with mFOLFOXIRI plus bevacizumab; Restaging; Concomitant Chemoradiotherapy; Surgery; Chemoradiotherapy (only when patients with MRF involved or ycT4a/b by restaging); Induction chemotherpay with FOLFOX. Conditions listed: Rectal Cancer. Primary outcome: Disease-free survival. Colorectal eligibility wording from the registry: \"Histological or cytological documentation of adenocarcinoma of the rectal (\\<12 cm from the anal verge)\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT04215731","url":"https://clinicaltrials.gov/study/NCT04215731"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04215731","phase":"3","setting":"Neoadjuvant mFOLFOXIRI Plus Bevacizumab Versus Induction FOLFOX Followed by Concomitant Chemoradiotherapy in Patients With High-Risk Locally Advanced Rectal Cancer: Multicenter Randomized Phase III Trial","sponsor":"Yanhong Deng","enrolled":582,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04215731/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}