{"entity":{"id":"nct04246684","kind":"trial","name":"Short RT Versus RCT,Followed by Chemo and Organ Preservation for Interm and High-risk Rectal Cancer Patients","aka":[],"tldr":"A phase 3 trial of fluorouracil (5-FU) in colorectal cancer, run by Prof. Dr. med. Claus Rödel, active but no longer recruiting.","summary":"Short RT Versus RCT,Followed by Chemo and Organ Preservation for Interm and High-risk Rectal Cancer Patients is a phase 3, randomised interventional study registered as NCT04246684 by Prof. Dr. med. Claus Rödel, with a registry enrolment figure of 702 participants, started 2020-11-05 and due to reach its primary completion in 2026-09-15. Interventions recorded: Oxaliplatin, 85 mg/m2; 5FU; 2400 mg/m2; 5FU, 250 mg/m2; 5FU, 2400 mg/m2; Oxaliplatin 50 mg/m2; Folinic Acid, 400 mg/m2; Radiotherapy control, 5x5 Gy: 25 Gy; Capecitabine, 1000 mg/m2; Oxaliplatin 85 mg/m2; radiotherapy experimental, 30 x 1,8 Gy: 54 Gy; Capecitabine, 825 mg/m2; Oxaliplatin, 130 mg/m2. Conditions listed: Rectal Cancer Stage III. Primary outcome: organ preservation. Colorectal eligibility wording from the registry: \"* diagnosis of rectal adenocarcinoma localised 0 - 12 cm from the anocutaneous line as measured by rigid rectoscopy (i\". Sites: Germany. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT04246684","url":"https://clinicaltrials.gov/study/NCT04246684"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","imrt-igrt"],"targets":[],"drugs":["fluorouracil"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04246684","phase":"3","setting":"Short-course Radiotherapy Versus Chemoradiotherapy, Followed by Consolidation Chemotherapy, and Selective Organ Preservation for MRI-defined Intermediate and High-risk Rectal Cancer Patients","sponsor":"Prof. Dr. med. Claus Rödel","enrolled":702,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04246684/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"fluorouracil","kind":"drug","name":"Fluorouracil (5-FU)","route":"/drugs/fluorouracil/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}