{"entity":{"id":"nct04274738","kind":"trial","name":"A Study of Mavorixafor in Combination With Ibrutinib in Participants With Waldenstrom's Macroglobulinemia (WM) Whose Tumors Express Mutations in MYD88 and CXCR4","aka":[],"tldr":"A phase 1 trial of Mavorixafor and Ibrutinib in Waldenström macroglobulinaemia, run by X4 Pharmaceuticals, completed.","summary":"A Study of Mavorixafor in Combination With Ibrutinib in Participants With Waldenstrom's Macroglobulinemia (WM) Whose Tumors Express Mutations in MYD88 and CXCR4 is a phase 1 interventional study registered as NCT04274738 by X4 Pharmaceuticals, with 16 participants recorded, started 2020-04-30 and reaching its primary completion in 2022-10-31. Interventions recorded: Mavorixafor, Ibrutinib. Conditions recorded: Waldenstrom's Macroglobulinemia.\n\nLinked to the drug Mavorixafor because the registry names it among its interventions and Waldenström macroglobulinaemia among its conditions. Registry record only: no result has been read by an editor.","status":"completed","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT04274738","url":"https://clinicaltrials.gov/study/NCT04274738"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["waldenstrom"],"sections":[],"technologies":[],"targets":[],"drugs":["mavorixafor","ibrutinib"],"companies":["x4-pharmaceuticals"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04274738","phase":"1","setting":"A Phase 1b Trial of Mavorixafor, an Oral CXCR4 Antagonist, in Combination With Ibrutinib in Patients With Waldenstrom's Macroglobulinemia (WM) Whose Tumors Express Mutations in MYD88 and CXCR4","sponsor":"X4 Pharmaceuticals","enrolled":16,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04274738/","neighbours":{"cancer":[{"id":"waldenstrom","kind":"cancer","name":"Waldenström macroglobulinaemia","route":"/cancers/waldenstrom/"}],"drug":[{"id":"ibrutinib","kind":"drug","name":"Ibrutinib","route":"/drugs/ibrutinib/"},{"id":"mavorixafor","kind":"drug","name":"Mavorixafor","route":"/drugs/mavorixafor/"}],"company":[{"id":"x4-pharmaceuticals","kind":"company","name":"X4 Pharmaceuticals","route":"/companies/x4-pharmaceuticals/"}]}}