{"entity":{"id":"nct04288999","kind":"trial","name":"Surgery Plus Chemo Versus Chemoradiotherapy Followed by Surgery Plus Chemo for Locally Recurrent Rectal Cancer","aka":["JCOG1801"],"tldr":"A phase 3 trial in colorectal cancer, run by National Cancer Center Hospital East, now recruiting.","summary":"Surgery Plus Chemo Versus Chemoradiotherapy Followed by Surgery Plus Chemo for Locally Recurrent Rectal Cancer is a phase 3, randomised interventional study registered as NCT04288999 by National Cancer Center Hospital East, with a registry enrolment figure of 110 participants, started 2019-10-01 and due to reach its primary completion in 2025-08. Interventions recorded: Chemotherapy; Preoperative radiotherapy; Procedure. Conditions listed: Rectal Cancer Recurrent. Primary outcome: Locally recurrent free survival. Colorectal eligibility wording from the registry: \"Histopathologically proven adenocarcinoma or adenosquamous carcinoma on the resected specimen of the initial rectal cancer or endoscopic biopsy from the initial rectal cancer\". Sites: Japan. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT04288999","url":"https://clinicaltrials.gov/study/NCT04288999"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04288999","phase":"3","setting":"JCOG1801: A Phase III Randomized Controlled Trial Comparing Surgery Plus Adjuvant Chemotherapy With Preoperative Chemoradiotherapy Followed by Surgery Plus Adjuvant Chemotherapy for Locally Recurrent Rectal Cancer (RC-SURVIVE Study)","sponsor":"National Cancer Center Hospital East","enrolled":110,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04288999/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}