{"entity":{"id":"nct04310592","kind":"trial","name":"Natural Killer Cell (CYNK-001) Infusions in Adults with AML","aka":[],"tldr":"A phase 1 trial of CYNK-001 run by Celularity Incorporated, terminated.","summary":"Natural Killer Cell (CYNK-001) Infusions in Adults with AML is a phase 1 interventional study registered as NCT04310592 by Celularity Incorporated, with 27 participants enrolled, started 2020-03-12. Conditions recorded: Leukemia, Leukemia, Myeloid, Leukemia, Myeloid, Acute, Neoplasms by Histologic Type, Neoplasms, Immunosuppressive Agents, Immunologic Factors, Physiological Effects of Drugs, Alkylating Agents, Antimetabolites, Antineoplastic, Antiviral Agents, Analgesics, Non-narcotic, Anti-infective Agents, Analgesics, Peripheral Nervous System Agents, Hematologic Diseases, Hematologic Neoplasms, Leukemia in Remission, Relapsed Adult AML and Refractory AML. Interventions recorded: CYNK-001.","status":"historic","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT04310592","url":"https://clinicaltrials.gov/study/NCT04310592"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["leukaemia","aml","metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["cynk-001"],"companies":["celularity"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04310592","phase":"1","setting":"A Phase I Multi-dose Study of Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK-001) with or Without Recombinant Human Interleukin-2 (rhIL-2) in Adults with Primary or Secondary Acute Myeloid Leukemia (AML) in Morphologic Complete Remission with Minimal Residual Disease (MRD) or Relapsed/refractory (R/R) AML","sponsor":"Celularity Incorporated","enrolled":27,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04310592/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"cynk-001","kind":"drug","name":"CYNK-001","route":"/drugs/cynk-001/"}],"company":[{"id":"celularity","kind":"company","name":"Celularity","route":"/companies/celularity/"}]}}