{"entity":{"id":"nct04315324","kind":"trial","name":"Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)","aka":[],"tldr":"A phase 1/2 trial of AST-3424 run by SWOG Cancer Research Network, active and no longer recruiting.","summary":"Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL) is a phase 1/2 interventional study registered as NCT04315324 by SWOG Cancer Research Network, with 67 participants planned, started 2021-02-08. Conditions recorded: Recurrent T Acute Lymphoblastic Leukemia, Refractory T Acute Lymphoblastic Leukemia, Refractory T Lymphoblastic Lymphoma and T Lymphoblastic Lymphoma. Interventions recorded: AKR1C3-activated Prodrug AST-3424, Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration and Computed Tomography.","status":"active","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT04315324","url":"https://clinicaltrials.gov/study/NCT04315324"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":["ast-3424"],"companies":["ascentawits-pharmaceuticals","obi-pharma","zhejiang-hisun"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04315324","phase":"1/2","setting":"A Phase I/II Study of AKR1C3-Activated Prodrug OBI-3424 (OBI-3424) In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)/T-Cell Lymphoblastic Lymphoma (T-LBL)","sponsor":"SWOG Cancer Research Network","enrolled":67,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04315324/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"}],"drug":[{"id":"ast-3424","kind":"drug","name":"AST-3424","route":"/drugs/ast-3424/"}],"company":[{"id":"ascentawits-pharmaceuticals","kind":"company","name":"Ascentawits Pharmaceuticals","route":"/companies/ascentawits-pharmaceuticals/"},{"id":"obi-pharma","kind":"company","name":"OBI Pharma","route":"/companies/obi-pharma/"},{"id":"zhejiang-hisun","kind":"company","name":"Zhejiang Hisun Pharmaceutical","route":"/companies/zhejiang-hisun/"}]}}