{"entity":{"id":"nct04335292","kind":"trial","name":"Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer with Osimertinib Third-line Rechallenge","aka":["OCELOT"],"tldr":"A phase 2 trial in lung cancer, run by Mark Vincent, now recruiting.","summary":"Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer with Osimertinib Third-line Rechallenge is a phase 2, interventional study registered as NCT04335292 by Mark Vincent, with a registry enrolment figure of 200 participants, started 2021-01-06 and due to reach its primary completion in 2026-06-01. Interventions recorded: Osimertinib First-Line; Platinum + Pemetrexed Chemotherapy Second-Line; Osimertinib Third-Line. Conditions listed: Non-Small Cell Lung Cancer. Primary outcome: Objective Response Rate according to Response Evaluation Criteria in Solid Tumors version 1.1. Lung eligibility wording from the registry: \"* Pathologically proven advanced non-small cell lung cancer (i\". Sites: Canada. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT04335292","url":"https://clinicaltrials.gov/study/NCT04335292"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["egfr-mutant-nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["astrazeneca"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04335292","phase":"2","setting":"Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer with Osimertinib Third-line Rechallenge","sponsor":"Mark Vincent","enrolled":200,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04335292/","neighbours":{"cancer":[{"id":"egfr-mutant-nsclc","kind":"cancer","name":"EGFR-mutated non-small-cell lung cancer","route":"/cancers/egfr-mutant-nsclc/"}],"company":[{"id":"astrazeneca","kind":"company","name":"AstraZeneca","route":"/companies/astrazeneca/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}