{"entity":{"id":"nct04349436","kind":"trial","name":"Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies","aka":[],"tldr":"A phase 1/2 trial of RP1, intra-tumoral injection, oncolytic virus in merkel cell carcinoma, basal cell carcinoma and cutaneous squamous cell carcinoma, run by Replimune, Inc., active and no longer recruiting.","summary":"Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies is a phase 1/2 interventional study registered as NCT04349436 by Replimune, Inc., with 69 participants enrolled, started 2020-05-15 and due to reach its primary completion in 2029-07. Interventions recorded: RP1, intra-tumoral injection, oncolytic virus.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04349436","url":"https://clinicaltrials.gov/study/NCT04349436"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["merkel-cell-carcinoma","basal-cell-carcinoma","cutaneous-scc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["replimune"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT04349436","phase":"1/2","setting":"An Open-Label, Multicenter, Phase 1B/2 Study of RP1 in Solid Organ and Hematopoietic Cell Transplant Recipients With Advanced Cutaneous Malignancies (ARTACUS)","sponsor":"Replimune, Inc.","enrolled":69,"outcomes":[]},"route":"/trials/nct04349436/","neighbours":{"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"cutaneous-scc","kind":"cancer","name":"Cutaneous squamous cell carcinoma","route":"/cancers/cutaneous-scc/"},{"id":"merkel-cell-carcinoma","kind":"cancer","name":"Merkel cell carcinoma","route":"/cancers/merkel-cell-carcinoma/"}],"company":[{"id":"replimune","kind":"company","name":"Replimune","route":"/companies/replimune/"}]}}