{"entity":{"id":"nct04416984","kind":"trial","name":"Safety and Efficacy of ALLO-501A Anti-CD19 Allogeneic CAR T Cells in Adults With Relapsed/Refractory Large B Cell Lymphoma, Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (ALPHA2)","aka":[],"tldr":"A phase 1/2 trial of ALLO-647, Fludarabine and Cyclophosphamide in chronic lymphocytic leukaemia, run by Allogene Therapeutics, active and no longer recruiting.","summary":"Safety and Efficacy of ALLO-501A Anti-CD19 Allogeneic CAR T Cells in Adults With Relapsed/Refractory Large B Cell Lymphoma, Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (ALPHA2) is a phase 1/2 interventional study registered as NCT04416984 by Allogene Therapeutics, with 160 participants enrolled, started 2020-05-21 and due to reach its primary completion in 2029-02. Interventions recorded: ALLO-501A, ALLO-647, Fludarabine and Cyclophosphamide.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04416984","url":"https://clinicaltrials.gov/study/NCT04416984"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["cll"],"sections":[],"technologies":[],"targets":[],"drugs":["allo-647","fludarabine","cyclophosphamide"],"companies":["allogene"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT04416984","phase":"1/2","setting":"A Single-Arm, Open-Label, Phase 1/2 Study Evaluating the Safety, Efficacy, and Cellular Kinetics/Pharmacodynamics of ALLO-501A, an Anti-CD19 Allogeneic CAR T Cell Therapy, and ALLO-647, an Anti-CD52 Monoclonal Antibody, in Subjects With Relapsed/Refractory Large B-Cell Lymphoma (LBCL)","sponsor":"Allogene Therapeutics","enrolled":160,"outcomes":[]},"route":"/trials/nct04416984/","neighbours":{"cancer":[{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"}],"drug":[{"id":"allo-647","kind":"drug","name":"ALLO-647","route":"/drugs/allo-647/"},{"id":"cyclophosphamide","kind":"drug","name":"Cyclophosphamide","route":"/drugs/cyclophosphamide/"},{"id":"fludarabine","kind":"drug","name":"Fludarabine","route":"/drugs/fludarabine/"}],"company":[{"id":"allogene","kind":"company","name":"Allogene Therapeutics","route":"/companies/allogene/"}]}}