{"entity":{"id":"nct04421820","kind":"trial","name":"BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours","aka":[],"tldr":"A phase 1/2 trial of Leucovorin, FLOT, Fluorouracil in colorectal cancer, run by Bold Therapeutics, Inc., now recruiting.","summary":"BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours is a phase 1/2 interventional study registered as NCT04421820 by Bold Therapeutics, Inc., with 220 participants planned, started 2020-08-28 and due to reach its primary completion in 2026-06-01. Interventions recorded: BOLD-100 +/- FOLFOX Chemotherapy (Arm VII), BOLD-100 in combination with FOLFOX Chemotherapy (Arms I-VI). Conditions listed: Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04421820","url":"https://clinicaltrials.gov/study/NCT04421820"}],"tags":["ctgov-ingest"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["leucovorin","flot","fluorouracil","capox"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT04421820","phase":"1/2","setting":"A Phase 1b/2a Dose Escalation Study of BOLD-100 in Combination With FOLFOX Chemotherapy in Patients With Advanced Solid Tumours","sponsor":"Bold Therapeutics, Inc.","enrolled":220,"outcomes":[]},"route":"/trials/nct04421820/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"drug":[{"id":"capox","kind":"drug","name":"CAPOX (capecitabine, oxaliplatin)","route":"/drugs/capox/"},{"id":"flot","kind":"drug","name":"FLOT (5-FU, leucovorin, oxaliplatin, docetaxel)","route":"/drugs/flot/"},{"id":"fluorouracil","kind":"drug","name":"Fluorouracil (5-FU)","route":"/drugs/fluorouracil/"},{"id":"leucovorin","kind":"drug","name":"Leucovorin (folinic acid)","route":"/drugs/leucovorin/"}]}}