{"entity":{"id":"nct04489420","kind":"trial","name":"Natural Killer Cell (CYNK-001) IV Infusion or IT Administration in Adults With Recurrent GBM","aka":[],"tldr":"A phase 1 trial of CYNK-001 run by Celularity Incorporated, terminated.","summary":"Natural Killer Cell (CYNK-001) IV Infusion or IT Administration in Adults With Recurrent GBM is a phase 1 interventional study registered as NCT04489420 by Celularity Incorporated, with 3 participants enrolled, started 2020-10-01. Conditions recorded: Astrocytoma, Grade IV, Giant Cell Glioblastoma, Glioblastoma Multiforme, Cyclophosphamide, Immunosuppressive Agents, Immunologic Factors, Physiological Effects of Drugs, Molecular Mechanisms of Pharmacological Action, Antiviral Agents, Anti-infective Agents, Analgesics, Non-narcotic, Analgesics, Sensory System Agents and Peripheral Nervous System Agents. Interventions recorded: CYNK001-IV and CYNK001-IT.","status":"historic","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT04489420","url":"https://clinicaltrials.gov/study/NCT04489420"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["brain-tumours","glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":["cynk-001"],"companies":["celularity"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04489420","phase":"1","setting":"A Phase I Study of Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK-001) in Adults With Recurrent Glioblastoma Multiforme (GBM)","sponsor":"Celularity Incorporated","enrolled":3,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04489420/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"drug":[{"id":"cynk-001","kind":"drug","name":"CYNK-001","route":"/drugs/cynk-001/"}],"company":[{"id":"celularity","kind":"company","name":"Celularity","route":"/companies/celularity/"}]}}