{"entity":{"id":"nct04516681","kind":"trial","name":"Combination of IV Ascorbic Acid and Adebrelimab in Metastatic Colorectal Cancer","aka":[],"tldr":"A phase 3 trial of adebrelimab in colorectal cancer, run by Fudan University, now recruiting.","summary":"Combination of IV Ascorbic Acid and Adebrelimab in Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT04516681 by Fudan University, with a registry enrolment figure of 400 participants, started 2024-12-01 and due to reach its primary completion in 2025-12-01. Interventions recorded: Ascorbic acid; FOLFOX Protocol; Adebrelimab. Conditions listed: Colorectal Cancer; Vitamin C; GLUT3. Primary outcome: Objective Response Rate. Colorectal eligibility wording from the registry: \"* Age≥18 years, ≤75 years; Histologically proven peritoneal metastatic adenocarcinoma of colorectal cancer, unresectable metastatic disease; IHC confirmed strong positive GLUT3; measurable disease; Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1; Life expectancy of at least 12 we\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT04516681","url":"https://clinicaltrials.gov/study/NCT04516681"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor"],"targets":[],"drugs":["adebrelimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04516681","phase":"3","setting":"Vitamin C Intravenously With Chemotherapy and Adebrelimab in Metastatic Colorectal Cancer With High Expresison Level of GLUT3","sponsor":"Fudan University","enrolled":400,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04516681/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"}],"drug":[{"id":"adebrelimab","kind":"drug","name":"Adebrelimab","route":"/drugs/adebrelimab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}