{"entity":{"id":"nct04553133","kind":"trial","name":"PF-07104091 as a Single Agent and in Combination Therapy","aka":[],"tldr":"A phase 2 trial of Palbociclib, Fulvestrant, Letrozole in small-cell lung cancer and ovarian cancer, run by Pfizer, active and no longer recruiting.","summary":"PF-07104091 as a Single Agent and in Combination Therapy is a phase 2 interventional study registered as NCT04553133 by Pfizer, with 157 participants enrolled, started 2020-09-16 and due to reach its primary completion in 2026-12-31. Interventions recorded: PF-07104091 monotherapy dose escalation, PF-07104091 + palbociclib + fulvestrant, PF-07104091 + palbociclib + letrozole, PF-07104091 monotherapy dose expansion (ovarian), PF-07104091 monotherapy dose expansion (SCLC). Conditions listed: Small Cell Lung Cancer, Ovarian Cancer, Breast Cancer. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04553133","url":"https://clinicaltrials.gov/study/NCT04553133"}],"tags":["ctgov-ingest"],"related":[],"cancers":["sclc","ovarian"],"sections":[],"technologies":[],"targets":[],"drugs":["palbociclib","fulvestrant","letrozole"],"companies":["pfizer"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT04553133","phase":"2","setting":"PHASE 1/2A DOSE ESCALATION, FINDING AND EXPANSION STUDY EVALUATING SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS AND ANTI TUMOR ACTIVITY OF PF-07104091 AS A SINGLE AGENT AND IN COMBINATION THERAPY","sponsor":"Pfizer","enrolled":157,"outcomes":[]},"route":"/trials/nct04553133/","neighbours":{"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"fulvestrant","kind":"drug","name":"Fulvestrant","route":"/drugs/fulvestrant/"},{"id":"letrozole","kind":"drug","name":"Letrozole (and other aromatase inhibitors)","route":"/drugs/letrozole/"},{"id":"palbociclib","kind":"drug","name":"Palbociclib","route":"/drugs/palbociclib/"}],"company":[{"id":"pfizer","kind":"company","name":"Pfizer (incl. Seagen)","route":"/companies/pfizer/"}]}}