{"entity":{"id":"nct04581473","kind":"trial","name":"Study to Evaluate the Efficacy, Safety and Pharmacokinetics of CT041 Autologous CAR T-cell Injection","aka":[],"tldr":"A phase 1/2 trial of Rivoceranib (apatinib) in gastric & gastro-oesophageal junction cancer and pancreatic ductal adenocarcinoma, run by CARsgen Therapeutics Co., Ltd., active and no longer recruiting.","summary":"Study to Evaluate the Efficacy, Safety and Pharmacokinetics of CT041 Autologous CAR T-cell Injection is a phase 1/2 interventional study registered as NCT04581473 by CARsgen Therapeutics Co., Ltd., with 192 participants enrolled, started 2020-10-23 and due to reach its primary completion in 2024-10-18. Interventions recorded: CT041 autologous CAR T-cell injection and Physician's Choice（Paclitaxel or Irinotecan or Apatinib or Anti-PD-1 antibody）.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04581473","url":"https://clinicaltrials.gov/study/NCT04581473"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["gastric","pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":["rivoceranib"],"companies":["carsgen"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT04581473","phase":"1/2","setting":"An Open, Multicenter, Phase Ib/II Study to Evaluate the Efficacy, Safety and Pharmacokinetics of CT041 Autologous CAR T-cell Injection in Patients With Advanced Gastric/ Gastroesophageal Junction Adenocarcinoma and Pancreatic Cancer","sponsor":"CARsgen Therapeutics Co., Ltd.","enrolled":192,"outcomes":[]},"route":"/trials/nct04581473/","neighbours":{"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"drug":[{"id":"rivoceranib","kind":"drug","name":"Rivoceranib (apatinib)","route":"/drugs/rivoceranib/"}],"company":[{"id":"carsgen","kind":"company","name":"CARsgen Therapeutics","route":"/companies/carsgen/"}]}}