{"entity":{"id":"nct04586231","kind":"trial","name":"A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)","aka":[],"tldr":"A phase 3 trial of Belzutifan, Lenvatinib and Cabozantinib in renal cell carcinoma, run by Merck Sharp & Dohme LLC, active and no longer recruiting.","summary":"A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011) is a phase 3 interventional study registered as NCT04586231 by Merck Sharp & Dohme LLC, with 747 participants enrolled, started 2021-02-25 and due to reach its primary completion in 2026-02-02. Interventions recorded: Belzutifan, Lenvatinib and Cabozantinib.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04586231","url":"https://clinicaltrials.gov/study/NCT04586231"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["rcc"],"sections":[],"technologies":[],"targets":[],"drugs":["belzutifan","lenvatinib","cabozantinib"],"companies":["merck","eisai"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT04586231","phase":"3","setting":"An Open-label, Randomized, Phase 3 Study of MK-6482 in Combination With Lenvatinib (MK-7902) vs Cabozantinib in Participants With Advanced Renal Cell Carcinoma Who Have Progressed After Prior Anti-PD-1/L1 Therapy","sponsor":"Merck Sharp & Dohme LLC","enrolled":747,"outcomes":[]},"route":"/trials/nct04586231/","neighbours":{"cancer":[{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}],"drug":[{"id":"belzutifan","kind":"drug","name":"Belzutifan","route":"/drugs/belzutifan/"},{"id":"cabozantinib","kind":"drug","name":"Cabozantinib","route":"/drugs/cabozantinib/"},{"id":"lenvatinib","kind":"drug","name":"Lenvatinib","route":"/drugs/lenvatinib/"}],"company":[{"id":"eisai","kind":"company","name":"Eisai","route":"/companies/eisai/"},{"id":"merck","kind":"company","name":"Merck & Co. (MSD)","route":"/companies/merck/"}]}}