{"entity":{"id":"nct04644068","kind":"trial","name":"Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies","aka":[],"tldr":"A phase 1/2 trial of Saruparib, Paclitaxel / nab-paclitaxel, Carboplatin in ovarian cancer and prostate cancer, run by AstraZeneca, active and no longer recruiting.","summary":"Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies is a phase 1/2 interventional study registered as NCT04644068 by AstraZeneca, with 702 participants enrolled, started 2020-11-12 and due to reach its primary completion in 2027-05-28. Interventions recorded: AZD5305, Paclitaxel, Carboplatin, T- Dxd, Dato-DXd. Conditions listed: Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04644068","url":"https://clinicaltrials.gov/study/NCT04644068"}],"tags":["ctgov-ingest"],"related":[],"cancers":["ovarian","prostate","nsclc","sclc","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["saruparib","paclitaxel","carboplatin","trastuzumab-deruxtecan","datopotamab-deruxtecan","camizestrant"],"companies":["astrazeneca"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT04644068","phase":"1/2","setting":"A Modular Phase I/IIa, Open-label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of Ascending Doses of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies","sponsor":"AstraZeneca","enrolled":702,"outcomes":[]},"route":"/trials/nct04644068/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"camizestrant","kind":"drug","name":"Camizestrant","route":"/drugs/camizestrant/"},{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"datopotamab-deruxtecan","kind":"drug","name":"Datopotamab deruxtecan","route":"/drugs/datopotamab-deruxtecan/"},{"id":"paclitaxel","kind":"drug","name":"Paclitaxel / nab-paclitaxel","route":"/drugs/paclitaxel/"},{"id":"saruparib","kind":"drug","name":"Saruparib","route":"/drugs/saruparib/"},{"id":"trastuzumab-deruxtecan","kind":"drug","name":"Trastuzumab deruxtecan","route":"/drugs/trastuzumab-deruxtecan/"}],"company":[{"id":"astrazeneca","kind":"company","name":"AstraZeneca","route":"/companies/astrazeneca/"}]}}