{"entity":{"id":"nct04650451","kind":"trial","name":"Safety and Activity Study of HER2-Targeted Dual Switch CAR-T Cells (BPX-603) in Subjects With HER2-Positive Solid Tumors","aka":[],"tldr":"A phase 1 trial of BPX-603 run by Bellicum Pharmaceuticals, suspended.","summary":"Safety and Activity Study of HER2-Targeted Dual Switch CAR-T Cells (BPX-603) in Subjects With HER2-Positive Solid Tumors is a phase 1 interventional study registered as NCT04650451 by Bellicum Pharmaceuticals, with 220 participants planned, started 2020-12-07. Conditions recorded: HER-2 Gene Amplification, HER2-positive Gastric Cancer, HER2-positive Breast Cancer, HER-2 Protein Overexpression and Solid Tumor, Adult. Interventions recorded: chimeric antigen receptor (CAR) T cell therapy.","status":"historic","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT04650451","url":"https://clinicaltrials.gov/study/NCT04650451"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["gastric-her2-positive","breast-her2-positive","metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["bpx-603"],"companies":["bellicum"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04650451","phase":"1","setting":"A Phase 1/2, Open-Label, Multicenter, Non-Randomized, Safety and Activity Study of HER2-Targeted Dual Switch CAR-T Cells (BPX-603) In Subjects With Previously Treated Advanced HER2-Positive Solid Tumors","sponsor":"Bellicum Pharmaceuticals","enrolled":220,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04650451/","neighbours":{"cancer":[{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"gastric-her2-positive","kind":"cancer","name":"HER2-positive gastric cancer","route":"/cancers/gastric-her2-positive/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"bpx-603","kind":"drug","name":"BPX-603","route":"/drugs/bpx-603/"}],"company":[{"id":"bellicum","kind":"company","name":"Bellicum Pharmaceuticals","route":"/companies/bellicum/"}]}}