{"entity":{"id":"nct04662580","kind":"trial","name":"ARX517/JNJ-95298177 as Monotherapy or Combination Therapy in Subjects With Metastatic Prostate Cancer","aka":[],"tldr":"A phase 1 trial of ARX517 alone or with apalutamide or abiraterone in metastatic prostate cancer, run by Janssen Research & Development, LLC, active but no longer recruiting.","summary":"ARX517/JNJ-95298177 as Monotherapy or Combination Therapy in Subjects With Metastatic Prostate Cancer is a phase 1 interventional study registered as NCT04662580 by Janssen Research & Development, LLC; 183 participants are planned, it started on 2021-05-03; the registry gives 2026-12-31 as its primary completion date. Interventions recorded: ARX517, Apalutamide, Abiraterone acetate, Prednisone. Conditions listed: Metastatic Prostate Cancer. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT04662580","url":"https://clinicaltrials.gov/study/NCT04662580"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":["arx517","apalutamide","abiraterone","prednisone"],"companies":["johnson-johnson"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04662580","phase":"1","setting":"A Phase 1, Multicenter, Open-Label, Dose-Escalation, and Dose-Expansion Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of ARX517 as Monotherapy and in Combination With Androgen Receptor Pathway Inhibitors in Subjects With Metastatic Prostate Cancer","sponsor":"Janssen Research & Development, LLC","started":"2021-05-03","enrolled":183,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04662580/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"drug":[{"id":"abiraterone","kind":"drug","name":"Abiraterone acetate","route":"/drugs/abiraterone/"},{"id":"apalutamide","kind":"drug","name":"Apalutamide","route":"/drugs/apalutamide/"},{"id":"arx517","kind":"drug","name":"ARX517","route":"/drugs/arx517/"},{"id":"prednisone","kind":"drug","name":"Prednisone","route":"/drugs/prednisone/"}],"company":[{"id":"johnson-johnson","kind":"company","name":"Johnson & Johnson","route":"/companies/johnson-johnson/"}]}}