{"entity":{"id":"nct04699188","kind":"trial","name":"Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation","aka":[],"tldr":"A phase 1/2 trial of JDQ443, TNO155 and Tislelizumab in non-small-cell lung cancer and colorectal cancer, run by Novartis Pharmaceuticals, active and no longer recruiting.","summary":"Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation is a phase 1/2 interventional study registered as NCT04699188 by Novartis Pharmaceuticals, with 344 participants enrolled, started 2021-02-24 and due to reach its primary completion in 2027-01-25. Interventions recorded: JDQ443, TNO155 and tislelizumab.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04699188","url":"https://clinicaltrials.gov/study/NCT04699188"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["nsclc","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["jdq443","tno155","tislelizumab"],"companies":["advanced-accelerator-applications"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT04699188","phase":"1/2","setting":"A Phase Ib/II Open-label, Multi-center Dose Escalation Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation","sponsor":"Novartis Pharmaceuticals","enrolled":344,"outcomes":[]},"route":"/trials/nct04699188/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"jdq443","kind":"drug","name":"JDQ443","route":"/drugs/jdq443/"},{"id":"tislelizumab","kind":"drug","name":"Tislelizumab","route":"/drugs/tislelizumab/"},{"id":"tno155","kind":"drug","name":"TNO155","route":"/drugs/tno155/"}],"company":[{"id":"advanced-accelerator-applications","kind":"company","name":"Advanced Accelerator Applications (Novartis)","route":"/companies/advanced-accelerator-applications/"}]}}