{"entity":{"id":"nct04711109","kind":"trial","name":"Denosumab for breast cancer prevention in BRCA1 carriers","aka":["Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation"],"tldr":"This study compares denosumab with placebo to see whether it prevents breast cancer in women with an inherited BRCA1 mutation. It is a prevention study rather than treatment for diagnosed cancer.","summary":"This study compares denosumab with placebo to see whether it prevents breast cancer in women with an inherited BRCA1 mutation. It is a prevention study rather than treatment for diagnosed cancer.\n\nInterventional study registered as NCT04711109, sponsored by Alliance for Clinical Trials in Oncology. Registry phase: 3. Registry enrollment is 300 participants (estimated). Registry status checked October 10, 2026: active not recruiting. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.","status":"active","asOf":"2026-10-10","links":[{"label":"ClinicalTrials.gov NCT04711109","url":"https://clinicaltrials.gov/study/NCT04711109"},{"label":"UCSF study listing and local availability","url":"https://clinicaltrials.ucsf.edu/trial/NCT04711109"}],"tags":["ucsf-breast-coverage","interventional"],"related":[],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["denosumab"],"companies":[],"institutions":["ucsf"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04711109","phase":"3","setting":"Breast cancer prevention in women with a germline BRCA1 mutation","sponsor":"Alliance for Clinical Trials in Oncology","participation":[{"nct":"NCT04711109","source":"https://clinicaltrials.gov/study/NCT04711109","fetchedAt":"2026-10-10T20:54:20.781933Z","studySha256":"c10e88f60401f27be5d0441a21088017b7a32b0f7d19971f7f20fc03daf6a1e0","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2026-10-05","leadSponsor":"Alliance for Clinical Trials in Oncology","collaboratorCount":2,"minimumAge":"25 Years","maximumAge":"55 Years","sex":"FEMALE","healthyVolunteers":true,"hasEligibility":true,"enrolment":300,"enrolmentType":"ESTIMATED","siteCount":47,"recruitingSiteCount":0,"countries":["United States"]}],"started":"2023-02-14","startedType":"actual","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04711109/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"drug":[{"id":"denosumab","kind":"drug","name":"Denosumab","route":"/drugs/denosumab/"}],"institution":[{"id":"ucsf","kind":"institution","name":"UCSF Helen Diller Family Comprehensive Cancer Center","route":"/institutions/ucsf/"}]}}