{"entity":{"id":"nct04725331","kind":"trial","name":"A Clinical Trial Assessing BT-001 Alone and in Combination With Pembrolizumab in Metastatic or Advanced Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of BT-001 run by Transgene, terminated.","summary":"A Clinical Trial Assessing BT-001 Alone and in Combination With Pembrolizumab in Metastatic or Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT04725331 by Transgene, with 31 participants enrolled, started 2021-02-25. Conditions recorded: Metastatic Cancer, Soft Tissue Sarcoma, Merkel Cell Carcinoma, Melanoma, Triple Negative Breast Cancer and Non Small Cell Lung Cancer. Interventions recorded: BT-001 and Pembrolizumab [KEYTRUDA®].","status":"historic","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT04725331","url":"https://clinicaltrials.gov/study/NCT04725331"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer","sarcoma","merkel-cell-carcinoma","melanoma","tnbc","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":["bt-001"],"companies":["bioinvent-international","transgene"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04725331","phase":"1/2","setting":"A Phase I/IIa Study of Intra-tumoral BT-001 (TG6030) Administered Alone and in Combination With Pembrolizumab in Patients With Cutaneous or, Subcutaneous Lesions or Easily Injectable Lymph Nodes of Metastatic/Advanced Solid Tumors.","sponsor":"Transgene","enrolled":31,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04725331/","neighbours":{"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"merkel-cell-carcinoma","kind":"cancer","name":"Merkel cell carcinoma","route":"/cancers/merkel-cell-carcinoma/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"drug":[{"id":"bt-001","kind":"drug","name":"BT-001","route":"/drugs/bt-001/"}],"company":[{"id":"bioinvent-international","kind":"company","name":"BioInvent International","route":"/companies/bioinvent-international/"},{"id":"transgene","kind":"company","name":"Transgene","route":"/companies/transgene/"}]}}