{"entity":{"id":"nct04736589","kind":"trial","name":"Inetetamab Plus Rapamycin and Chemotherapy for HER2+ Metastatic Breast Cancer With Abnormal Activation of PAM Pathway","aka":[],"tldr":"A phase 3 trial of Inetetamab, Sirolimus protein-bound particles and Pyrotinib in Breast cancer, run by Peking Union Medical College, not yet recruiting.","summary":"Inetetamab Plus Rapamycin and Chemotherapy for HER2+ Metastatic Breast Cancer With Abnormal Activation of PAM Pathway is a phase 3 interventional study registered as NCT04736589 by Peking Union Medical College, with 270 participants planned, started 2021-02-02 and due to reach its primary completion in 2024-02-02. Interventions recorded: Inetetamab, Rapamycin, Pyrotinib, Chemotherapy. Conditions recorded: Breast Cancer.\n\nLinked to the drug Inetetamab because the registry names it among its interventions and Breast cancer among its conditions. Registry record only: no result has been read by an editor.","status":"planned","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT04736589","url":"https://clinicaltrials.gov/study/NCT04736589"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["inetetamab","sirolimus-albumin-bound","pyrotinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04736589","phase":"3","setting":"Efficacy and Safety of Inetetamab Combined With Rapamycin and Chemotherapy for HER2-positive Metastatic Breast Cancer Patients With Abnormal Activation of PI3K/Akt/mTOR Pathway After Progression on Trastuzumab.","sponsor":"Peking Union Medical College","enrolled":270,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04736589/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"drug":[{"id":"inetetamab","kind":"drug","name":"Inetetamab","route":"/drugs/inetetamab/"},{"id":"pyrotinib","kind":"drug","name":"Pyrotinib","route":"/drugs/pyrotinib/"},{"id":"sirolimus-albumin-bound","kind":"drug","name":"Sirolimus protein-bound particles","route":"/drugs/sirolimus-albumin-bound/"}]}}