{"entity":{"id":"nct04749108","kind":"trial","name":"Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma","aka":["GRECCAR14"],"tldr":"A phase 2/3 trial in colorectal cancer, run by Institut du Cancer de Montpellier - Val d'Aurelle, now recruiting.","summary":"Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma is a phase 2/3, randomised interventional study registered as NCT04749108 by Institut du Cancer de Montpellier - Val d'Aurelle, with a registry enrolment figure of 1075 participants, started 2021-11-26 and due to reach its primary completion in 2029-09. Interventions recorded: Induction chemotherapy - modified FOLFIRINOX regimen; Early tumor response evaluation by MRI volumetry; Radiochemotherapy Cap 50; Radical proctectomy with total mesorectal excision. Conditions listed: Locally Advanced Malignant Neoplasm; Rectal Carcinoma. Primary outcome: R0 resection rate (R0 is defined as Circumferential resection margin (CRM ≥ 1 mm) for Phase II; 3-year Disease free survival (DFS) for Phase III. Colorectal eligibility wording from the registry: \"Histologically confirmed diagnosis of adenocarcinoma of the rectum,\". Sites: France. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT04749108","url":"https://clinicaltrials.gov/study/NCT04749108"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04749108","phase":"2/3","setting":"Multicentric Phase II-III Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma After a Favorable Response to Induction Chemotherapy","sponsor":"Institut du Cancer de Montpellier - Val d'Aurelle","enrolled":1075,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04749108/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}