{"entity":{"id":"nct04789486","kind":"trial","name":"Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer","aka":[],"tldr":"A phase 1/2 trial in pancreatic cancer, run by Dana-Farber Cancer Institute, now recruiting.","summary":"Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer is a phase 1/2, randomised interventional study registered as NCT04789486 by Dana-Farber Cancer Institute, with a registry enrolment figure of 100 participants, started 2021-05-27 and due to reach its primary completion in 2028-04-10. Interventions recorded: AGuIX; Radiotherapy. Conditions listed: Non-small Cell Lung Cancer; Advanced Pancreatic Adenocarcinoma; Unresectable Pancreatic Cancer; Ductal Adenocarcinoma of the Pancreas. Primary outcome: Maximum tolerated dose (MTD) Phase 1; Compare Local Control at 12 months of Maximum tolerated dose MTD - Phase 2. Pancreatic eligibility wording from the registry: \"OR Histologically or cytologically confirmed pancreatic ductal adenocarcinoma of the pancreatic head, body or tail\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT04789486","url":"https://clinicaltrials.gov/study/NCT04789486"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["locally-advanced-pdac"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04789486","phase":"1/2","setting":"Nano-SMART: An Adaptive Phase I-II Trial of AGuIX Gadolinium-based Nanoparticles With Stereotactic Magnetic Resonance-guided Adaptive Radiation Therapy for Centrally Located Lung Tumors and Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma","sponsor":"Dana-Farber Cancer Institute","enrolled":100,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04789486/","neighbours":{"cancer":[{"id":"locally-advanced-pdac","kind":"cancer","name":"Locally advanced unresectable pancreatic ductal adenocarcinoma","route":"/cancers/locally-advanced-pdac/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}