{"entity":{"id":"nct04861558","kind":"trial","name":"Efficacy of Hyperthermic Intraperitoneal Chemotherapy","aka":["EFFIPEC"],"tldr":"A phase 3 trial of fOLFIRI (5-FU, leucovorin, irinotecan) and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Uppsala University, now recruiting.","summary":"Efficacy of Hyperthermic Intraperitoneal Chemotherapy is a phase 3, randomised interventional study registered as NCT04861558 by Uppsala University, with a registry enrolment figure of 213 participants, started 2021-05-01 and due to reach its primary completion in 2025-12. Interventions recorded: 5Fluorouracil; Irinotecan; Oxaliplatin. Conditions listed: Colorectal Cancer; Peritoneal Metastases. Primary outcome: Recurrence-free survival. Colorectal eligibility wording from the registry: \"Colorectal cancer with peritoneal metastases +/- liver metastases (maximum 3)\". Sites: India, Sweden. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT04861558","url":"https://clinicaltrials.gov/study/NCT04861558"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","hipec","platinum","topoisomerase-inhibitors"],"targets":[],"drugs":["folfiri","folfox"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04861558","phase":"3","setting":"EFFIPEC - Efficacy of Hyperthermic Intraperitoneal Chemotherapy, Single-arm Phase I Study, Followed by an Open-label, Randomized, Controlled Registry-based Phase III Trial","sponsor":"Uppsala University","enrolled":213,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04861558/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"hipec","kind":"technology","name":"HIPEC / PIPAC (intraperitoneal chemotherapy)","route":"/technologies/hipec/"},{"id":"platinum","kind":"technology","name":"Platinum agents","route":"/technologies/platinum/"},{"id":"topoisomerase-inhibitors","kind":"technology","name":"Topoisomerase-I inhibitors (and ADC payloads)","route":"/technologies/topoisomerase-inhibitors/"}],"drug":[{"id":"folfiri","kind":"drug","name":"FOLFIRI (5-FU, leucovorin, irinotecan)","route":"/drugs/folfiri/"},{"id":"folfox","kind":"drug","name":"FOLFOX (5-FU, leucovorin, oxaliplatin)","route":"/drugs/folfox/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}