{"entity":{"id":"nct04868877","kind":"trial","name":"Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combina","aka":[],"tldr":"A phase 1/2 trial of MCLA-129, Osimertinib in non-small-cell lung cancer and small-cell lung cancer, run by Merus B.V., active and no longer recruiting.","summary":"Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination is a phase 1/2 interventional study registered as NCT04868877 by Merus B.V., with 194 participants enrolled, started 2021-04-28 and due to reach its primary completion in 2026-03. Interventions recorded: MCLA-129, Osimertinib, Chemotherapy. Conditions listed: Non-Small Cell Lung Cancer Metastatic, Gastric Cancer, Esophageal Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04868877","url":"https://clinicaltrials.gov/study/NCT04868877"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc","sclc","head-and-neck","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["mcla-129","osimertinib"],"companies":["genmab"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT04868877","phase":"1/2","setting":"Phase 1/2 Dose Escalation and Expansion Study Evaluating MCLA-129, a Human Anti-EGFR and Anti-c-MET Bispecific Antibody, in Patients With Advanced NSCLC and Other Solid Tumors","sponsor":"Merus B.V.","enrolled":194,"outcomes":[]},"route":"/trials/nct04868877/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"mcla-129","kind":"drug","name":"MCLA-129","route":"/drugs/mcla-129/"},{"id":"osimertinib","kind":"drug","name":"Osimertinib","route":"/drugs/osimertinib/"}],"company":[{"id":"genmab","kind":"company","name":"Genmab","route":"/companies/genmab/"}]}}