{"entity":{"id":"nct04922853","kind":"trial","name":"Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer","aka":["COPEC"],"tldr":"A phase 3 trial in colorectal cancer, run by West China Hospital, active but no longer recruiting.","summary":"Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer is a phase 3, randomised interventional study registered as NCT04922853 by West China Hospital, with a registry enrolment figure of 554 participants, started 2021-08-26 and due to reach its primary completion in 2024-10-01. Interventions recorded: Capox chemotherapy. Conditions listed: Rectal Cancer; Neoadjuvant Chemotherapy. Primary outcome: pathological Tumor Regression Grade evaluation. Colorectal eligibility wording from the registry: \"Patients diagnosed with low/intermediate risk stage II/III rectal cancer under MRI and transanal ultrasound,defined as: low:T3a-bN0-1M0, EMVI (±), MRF (-) (≥2mm); Middle-high rectal cancer: T3a-cN0-1M0, EMVI (±), MRF (-) (≥2mm); No more than 3 lymph nodes with short diameter over 8mm or highly suspe\". Sites: China. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT04922853","url":"https://clinicaltrials.gov/study/NCT04922853"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04922853","phase":"3","setting":"Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer：a Prospective, Non-inferior, Randomized, Controlled Trial","sponsor":"West China Hospital","enrolled":554,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04922853/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}