{"entity":{"id":"nct04935229","kind":"trial","name":"Intrahepatic Delivery of SD-101 by Pressure-Enabled Regional Immuno-oncology (PERIO), With Checkpoint Blockade in Adults With Metastatic Uveal Melanoma","aka":[],"tldr":"A phase 1 trial of Nelitolimod run by TriSalus Life Sciences, Inc., terminated.","summary":"Intrahepatic Delivery of SD-101 by Pressure-Enabled Regional Immuno-oncology (PERIO), With Checkpoint Blockade in Adults With Metastatic Uveal Melanoma is a phase 1 interventional study registered as NCT04935229 by TriSalus Life Sciences, Inc., with 67 participants enrolled, started 2021-08-02, primary completion reached 2024-07-17. Conditions recorded: Metastatic Uveal Melanoma in the Liver. Interventions recorded: SD-101, Nivolumab, Ipilimumab, Nivolumab and Relatlimab. Reason given for stopping: The decision was made to terminate the study after the completion of Phase 1 enrollment and not proceed with Phase 2. Trial termination was not due to patient safety or data concerns.","status":"historic","asOf":"2026-11-04","links":[{"label":"ClinicalTrials.gov NCT04935229","url":"https://clinicaltrials.gov/study/NCT04935229"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["uveal-melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":["nelitolimod"],"companies":["trisalus-life-sciences"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04935229","phase":"1","setting":"A Phase 1/1b, Open-Label Study of the Pressure-Enabled Hepatic Artery Infusion of SD-101, a TLR9 Agonist, Alone or in Combination With Intravenous Checkpoint Blockade in Adults With Metastatic Uveal Melanoma","sponsor":"TriSalus Life Sciences, Inc.","enrolled":67,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04935229/","neighbours":{"cancer":[{"id":"uveal-melanoma","kind":"cancer","name":"Uveal melanoma","route":"/cancers/uveal-melanoma/"}],"drug":[{"id":"nelitolimod","kind":"drug","name":"Nelitolimod","route":"/drugs/nelitolimod/"}],"company":[{"id":"trisalus-life-sciences","kind":"company","name":"TriSalus Life Sciences","route":"/companies/trisalus-life-sciences/"}]}}