{"entity":{"id":"nct05007132","kind":"trial","name":"Trifluridine/ Tipiracil Plus Panitumumab Versus Trifluridine/ Tipiracil Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer","aka":[],"tldr":"A phase 2 trial of bevacizumab (glioblastoma use) in colorectal cancer, run by Dominik Paul Modest, now recruiting.","summary":"Trifluridine/ Tipiracil Plus Panitumumab Versus Trifluridine/ Tipiracil Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer is a phase 2, randomised interventional study registered as NCT05007132 by Dominik Paul Modest, with a registry enrolment figure of 153 participants, started 2021-12-17 and due to reach its primary completion in 2029-12. Interventions recorded: Panitumumab 20 milligram/ML; Bevacizumab; Trifluridine/Tipiracil Hydrochloride. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: Objective response rate. Colorectal eligibility wording from the registry: \"Histologically confirmed adenocarcinoma of the colon or rectum\". Sites: Germany. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05007132","url":"https://clinicaltrials.gov/study/NCT05007132"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["bevacizumab-glioma"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05007132","phase":"2","setting":"Prospective, Randomized, Open, Multicenter Phase II Trial to Investigate the Efficacy of Trifluridine/Tipiracil Plus Panitumumab Versus Trifluridine/Tipiracil Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer: FIRE-8; AIO-KRK/YMO-0519","sponsor":"Dominik Paul Modest","enrolled":153,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05007132/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"drug":[{"id":"bevacizumab-glioma","kind":"drug","name":"Bevacizumab (glioblastoma use)","route":"/drugs/bevacizumab-glioma/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}