{"entity":{"id":"nct05009992","kind":"trial","name":"Combination Therapy for the Treatment of Diffuse Midline Gliomas","aka":[],"tldr":"A phase 2 trial of DNX-2401 run by University of California, San Francisco, now recruiting.","summary":"Combination Therapy for the Treatment of Diffuse Midline Gliomas is a phase 2 interventional study registered as NCT05009992 by University of California, San Francisco, with 360 participants planned, started 2021-10-20. Conditions recorded: Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant, Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Diffuse Midline Glioma, H3 K27M-Mutant, Recurrent WHO Grade III Glioma and WHO Grade III Glioma. Interventions recorded: ONC201, Radiation Therapy, Paxalisib and DNX-2401.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT05009992","url":"https://clinicaltrials.gov/study/NCT05009992"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["dipg-dmg","brain-tumours"],"sections":[],"technologies":[],"targets":[],"drugs":["dnx-2401"],"companies":["dnatrix"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05009992","phase":"2","setting":"A Combination Therapy Trial Using an Adaptive Platform Design for Children and Young Adults With Diffuse Midline Gliomas (DMGs) Including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial Diagnosis, Post-Radiation Therapy and at Time of Progression","sponsor":"University of California, San Francisco","enrolled":360,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05009992/","neighbours":{"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"dipg-dmg","kind":"cancer","name":"Diffuse midline glioma, H3 K27-altered (including DIPG)","route":"/cancers/dipg-dmg/"}],"drug":[{"id":"dnx-2401","kind":"drug","name":"DNX-2401","route":"/drugs/dnx-2401/"}],"company":[{"id":"dnatrix","kind":"company","name":"DNAtrix","route":"/companies/dnatrix/"}]}}