{"entity":{"id":"nct05107674","kind":"trial","name":"NX-1607 in advanced malignancies","aka":["A Study of NX-1607 in Adults With Advanced Malignancies"],"tldr":"This early study tests NX-1607 alone or with paclitaxel in selected advanced cancers. It seeks a tolerable dose and early evidence of treatment activity.","summary":"This early study tests NX-1607 alone or with paclitaxel in selected advanced cancers. It seeks a tolerable dose and early evidence of treatment activity.\n\nInterventional study registered as NCT05107674, sponsored by Nurix Therapeutics, Inc.. Registry phase: 1. Registry enrollment is 345 participants (estimated). Registry status checked October 10, 2026: recruiting. UCSF lists this study as open to eligible people; local availability and overall registry status are separate. See the registry for full eligibility and current sites.","status":"recruiting","asOf":"2026-10-10","links":[{"label":"ClinicalTrials.gov NCT05107674","url":"https://clinicaltrials.gov/study/NCT05107674"},{"label":"UCSF study listing and local availability","url":"https://clinicaltrials.ucsf.edu/trial/NCT05107674"}],"tags":["ucsf-breast-coverage","interventional"],"related":[],"cancers":["breast-cancer","tnbc"],"sections":[],"technologies":[],"targets":[],"drugs":["paclitaxel"],"companies":[],"institutions":["ucsf"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05107674","phase":"1","setting":"Selected advanced cancers, including triple-negative breast cancer","sponsor":"Nurix Therapeutics, Inc.","participation":[{"nct":"NCT05107674","source":"https://clinicaltrials.gov/study/NCT05107674","fetchedAt":"2026-10-10T20:54:18.913369Z","studySha256":"13fd6f5034e1b5a9b021f93e491bf9c04046e63a98674d4e38bd8e204422b100","overallStatus":"RECRUITING","lastUpdatePosted":"2025-09-09","leadSponsor":"Nurix Therapeutics, Inc.","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":345,"enrolmentType":"ESTIMATED","siteCount":17,"recruitingSiteCount":15,"countries":["United Kingdom","United States"]}],"started":"2021-09-29","startedType":"actual","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05107674/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"drug":[{"id":"paclitaxel","kind":"drug","name":"Paclitaxel / nab-paclitaxel","route":"/drugs/paclitaxel/"}],"institution":[{"id":"ucsf","kind":"institution","name":"UCSF Helen Diller Family Comprehensive Cancer Center","route":"/institutions/ucsf/"}]}}