{"entity":{"id":"nct05143996","kind":"trial","name":"CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)","aka":[],"tldr":"A phase 1/2 trial of CLN-049 run by Cullinan Therapeutics Inc., now recruiting.","summary":"CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) is a phase 1/2 interventional study registered as NCT05143996 by Cullinan Therapeutics Inc., with 275 participants planned, started 2021-11-18. Conditions recorded: Relapsed/Refractory Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) and TP53-mutated MDS and AML. Interventions recorded: CLN-049.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT05143996","url":"https://clinicaltrials.gov/study/NCT05143996"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["aml","mds","metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["cln-049"],"companies":["cullinan-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05143996","phase":"1/2","setting":"A Phase 1/2, Open-label, Preliminary Pharmacokinetics (PK) and Safety Study of CLN-049 (An Fms-like Tyrosine Kinase 3 [FLT3] x Cluster of Differentiation 3 [CD3] Bispecific T Cell Engager) in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)","sponsor":"Cullinan Therapeutics Inc.","enrolled":275,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05143996/","neighbours":{"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}],"drug":[{"id":"cln-049","kind":"drug","name":"CLN-049","route":"/drugs/cln-049/"}],"company":[{"id":"cullinan-therapeutics","kind":"company","name":"Cullinan Therapeutics","route":"/companies/cullinan-therapeutics/"}]}}