{"entity":{"id":"nct05186753","kind":"trial","name":"(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis","aka":[],"tldr":"A phase 2 trial of Bezuclastinib in systemic mastocytosis, run by Cogent Biosciences, Inc., active and no longer recruiting.","summary":"(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis is a phase 2 interventional study registered as NCT05186753 by Cogent Biosciences, Inc., with 237 participants planned, started 2022-06-27 and due to reach its primary completion in 2025-05-22. Interventions recorded: Bezuclastinib Tablets (Formulation A), Bezuclastinib Tablets (Formulation B), Placebo Tablets. Conditions listed: SSM, Mastocytosis, Indolent, Mastocytosis, Systemic, Mastocytosis. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05186753","url":"https://clinicaltrials.gov/study/NCT05186753"}],"tags":["ctgov-ingest"],"related":[],"cancers":["systemic-mastocytosis"],"sections":[],"technologies":[],"targets":[],"drugs":["bezuclastinib"],"companies":["cogent-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05186753","phase":"2","setting":"A Multi-Part, Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Study of The Safety and Efficacy of CGT9486 in Subjects With Nonadvanced Systemic Mastocytosis","sponsor":"Cogent Biosciences, Inc.","enrolled":237,"outcomes":[]},"route":"/trials/nct05186753/","neighbours":{"cancer":[{"id":"systemic-mastocytosis","kind":"cancer","name":"Systemic mastocytosis","route":"/cancers/systemic-mastocytosis/"}],"drug":[{"id":"bezuclastinib","kind":"drug","name":"Bezuclastinib","route":"/drugs/bezuclastinib/"}],"company":[{"id":"cogent-biosciences","kind":"company","name":"Cogent Biosciences","route":"/companies/cogent-biosciences/"}]}}