{"entity":{"id":"nct05236946","kind":"trial","name":"Observation or Upfront Cranial RT in Oncogene Mutated NSCLC With Asymptomatic BM: A Phase III RCT","aka":[],"tldr":"A phase 3 trial in lung cancer, run by Tata Memorial Hospital, now recruiting.","summary":"Observation or Upfront Cranial RT in Oncogene Mutated NSCLC With Asymptomatic BM: A Phase III RCT is a phase 3, randomised interventional study registered as NCT05236946 by Tata Memorial Hospital, with a registry enrolment figure of 190 participants, started 2020-11-10 and due to reach its primary completion in 2025-12. Interventions recorded: Stereotactic radiosurgery/whole brain radiotherapy; Tyrosine kinase inhibitor. Conditions listed: Asymptomatic Brain Metastases; Driver Mutation Positive Non-small Cell Lung Cancer. Primary outcome: Intracranial progression free survival at 24 months. Lung eligibility wording from the registry: \"Patients with pathologically proven diagnosis of NSCLC\". Sites: India. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT05236946","url":"https://clinicaltrials.gov/study/NCT05236946"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05236946","phase":"3","setting":"Observation or Upfront Cranial RT in Oncogene Driver Mutated NSCLC With Asymptomatic Brain Metastases: A Phase III Randomized Controlled Trial","sponsor":"Tata Memorial Hospital","enrolled":190,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05236946/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}