{"entity":{"id":"nct05245474","kind":"trial","name":"Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Beijing Friendship Hospital, now recruiting.","summary":"Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT05245474 by Beijing Friendship Hospital, with a registry enrolment figure of 186 participants, started 2022-04-01 and due to reach its primary completion in 2024-03-01. Interventions recorded: Long-course chemoradiation, with or without Tislelizumab (PD-1 inhibitor). Conditions listed: Locally Advanced Rectal Cancer. Primary outcome: pCR rate. Colorectal eligibility wording from the registry: \"* biopsy diagnosed rectal adenocarcinoma, distal margin within 10cm to anal verge\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05245474","url":"https://clinicaltrials.gov/study/NCT05245474"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":["beone"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05245474","phase":"2","setting":"Efficacy and Safety of Neoadjuvant Long-course Chemoradiation Plus Tislelizumab in Mid-low Locally Advanced Rectal Cancer: a Phase II, Multi-center, Open-label, Randomized Controlled Trial (POLARSTAR Trial)","sponsor":"Beijing Friendship Hospital","enrolled":186,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05245474/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"company":[{"id":"beone","kind":"company","name":"BeOne Medicines (formerly BeiGene)","route":"/companies/beone/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}