{"entity":{"id":"nct05253651","kind":"trial","name":"A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer","aka":[],"tldr":"A phase 3 trial of Tucatinib, Trastuzumab, Bevacizumab, Cetuximab and Oxaliplatin in colorectal cancer, run by Seagen, a wholly owned subsidiary of Pfizer, now recruiting.","summary":"A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer is a phase 3 interventional study registered as NCT05253651 by Seagen, a wholly owned subsidiary of Pfizer, with 400 participants planned, started 2022-10-24 and due to reach its primary completion in 2027-12-31. Interventions recorded: tucatinib, trastuzumab, bevacizumab, cetuximab, oxaliplatin and leucovorin.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05253651","url":"https://clinicaltrials.gov/study/NCT05253651"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["tucatinib","trastuzumab","bevacizumab","cetuximab","oxaliplatin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05253651","phase":"3","setting":"An Open-label Randomized Phase 3 Study of Tucatinib in Combination With Trastuzumab and mFOLFOX6 Versus mFOLFOX6 Given With or Without Either Cetuximab or Bevacizumab as First-line Treatment for Subjects With HER2+ Metastatic Colorectal Cancer","sponsor":"Seagen, a wholly owned subsidiary of Pfizer","enrolled":400,"outcomes":[]},"route":"/trials/nct05253651/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"drug":[{"id":"bevacizumab","kind":"drug","name":"Bevacizumab","route":"/drugs/bevacizumab/"},{"id":"cetuximab","kind":"drug","name":"Cetuximab","route":"/drugs/cetuximab/"},{"id":"oxaliplatin","kind":"drug","name":"Oxaliplatin","route":"/drugs/oxaliplatin/"},{"id":"trastuzumab","kind":"drug","name":"Trastuzumab","route":"/drugs/trastuzumab/"},{"id":"tucatinib","kind":"drug","name":"Tucatinib","route":"/drugs/tucatinib/"}]}}