{"entity":{"id":"nct05254327","kind":"trial","name":"Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by University of Nebraska, now recruiting.","summary":"Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001 is a phase 2, randomised interventional study registered as NCT05254327 by University of Nebraska, with a registry enrolment figure of 118 participants, started 2022-08-15 and due to reach its primary completion in 2027-05. Interventions recorded: BMX-001. Conditions listed: Rectal Cancer. Primary outcome: Efficacy of BMX-001 as measured by Grade 3 and above associated with gastrointestinal Toxicities; Efficacy of BMX-001 as measured by Grade 3 and above associated with genitourinary Toxicities; Efficacy of BMX-001 as measured by Grade 3 and above associated with skin Toxicities. Colorectal eligibility wording from the registry: \"Patients with pathologically confirmed locally advanced rectal adenocarcinoma who will be receiving total neoadjuvant therapy regimen with curative intent\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05254327","url":"https://clinicaltrials.gov/study/NCT05254327"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05254327","phase":"2","setting":"A Randomized Phase 2 Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With and Without BMX-001 as Part of Total Neoadjuvant Therapy in Patients With Newly Diagnosed Locally Advanced Rectal Adenocarcinoma","sponsor":"University of Nebraska","enrolled":118,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05254327/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}