{"entity":{"id":"nct05256290","kind":"trial","name":"Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations","aka":[],"tldr":"A phase 1/2 trial of Silevertinib in non-small-cell lung cancer and small-cell lung cancer, run by Black Diamond Therapeutics, Inc., active and no longer recruiting.","summary":"Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations is a phase 1/2 interventional study registered as NCT05256290 by Black Diamond Therapeutics, Inc., with 200 participants planned, started 2022-03-31 and due to reach its primary completion in 2025-11-03. Interventions recorded: silevertinib (BDTX-1535) monotherapy. Conditions listed: Non-Small Cell Lung Cancer, Advanced Non-Small Cell Squamous Lung Cancer, Metastatic Lung Non-Small Cell Carcinoma, Metastatic Lung Cancer. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05256290","url":"https://clinicaltrials.gov/study/NCT05256290"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc","sclc"],"sections":[],"technologies":[],"targets":[],"drugs":["silevertinib"],"companies":["black-diamond-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05256290","phase":"1/2","setting":"A Phase 1/2 Study to Assess BDTX-1535, an Oral EGFR Inhibitor, in Patients With Glioblastoma or Non-Small Cell Lung Cancer","sponsor":"Black Diamond Therapeutics, Inc.","enrolled":200,"outcomes":[]},"route":"/trials/nct05256290/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"drug":[{"id":"silevertinib","kind":"drug","name":"Silevertinib","route":"/drugs/silevertinib/"}],"company":[{"id":"black-diamond-therapeutics","kind":"company","name":"Black Diamond Therapeutics","route":"/companies/black-diamond-therapeutics/"}]}}