{"entity":{"id":"nct05329766","kind":"trial","name":"A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies","aka":[],"tldr":"A phase 2 trial of Domvanalimab, Quemliclustat, Zimberelimab and Oxaliplatin in advanced solid tumours, run by Arcus Biosciences, Inc., active and no longer recruiting.","summary":"A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies is a phase 2 interventional study registered as NCT05329766 by Arcus Biosciences, Inc., with 332 participants enrolled, started 2022-06-10 and due to reach its primary completion in 2027-01. Interventions recorded: Domvanalimab, Quemliclustat, Zimberelimab, Fluorouracil, Leucovorin and Oxaliplatin.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05329766","url":"https://clinicaltrials.gov/study/NCT05329766"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["domvanalimab","quemliclustat","zimberelimab","oxaliplatin"],"companies":["arcus-biosciences","gilead"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT05329766","phase":"2","setting":"A Phase 2 Trial to Evaluate the Safety and Efficacy of Combination Therapies in Patients With Advanced Upper Gastrointestinal Tract Malignancies (EDGE-Gastric)","sponsor":"Arcus Biosciences, Inc.","enrolled":332,"outcomes":[]},"route":"/trials/nct05329766/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"domvanalimab","kind":"drug","name":"Domvanalimab","route":"/drugs/domvanalimab/"},{"id":"oxaliplatin","kind":"drug","name":"Oxaliplatin","route":"/drugs/oxaliplatin/"},{"id":"quemliclustat","kind":"drug","name":"Quemliclustat","route":"/drugs/quemliclustat/"},{"id":"zimberelimab","kind":"drug","name":"Zimberelimab","route":"/drugs/zimberelimab/"}],"company":[{"id":"arcus-biosciences","kind":"company","name":"Arcus Biosciences","route":"/companies/arcus-biosciences/"},{"id":"gilead","kind":"company","name":"Gilead Sciences (incl. Kite)","route":"/companies/gilead/"}]}}