{"entity":{"id":"nct05356741","kind":"trial","name":"To Access the Safety and Effects of Intravenous Administration of VIR-5818 Alone and in Combination With Pembrolizumab in Adult Participants With Locally Advanced or Metastatic HER2-Expressing Cancers","aka":[],"tldr":"A phase 1/2 trial of VIR-5818 run by Vir Biotechnology, Inc., now recruiting.","summary":"To Access the Safety and Effects of Intravenous Administration of VIR-5818 Alone and in Combination With Pembrolizumab in Adult Participants With Locally Advanced or Metastatic HER2-Expressing Cancers is a phase 1/2 interventional study registered as NCT05356741 by Vir Biotechnology, Inc., with 645 participants planned, started 2022-04-13. Conditions recorded: Locally Advanced or Metastatic HER2-Expressing Cancers. Interventions recorded: VIR-5818 and pembrolizumab.","status":"recruiting","asOf":"2026-11-03","links":[{"label":"ClinicalTrials.gov NCT05356741","url":"https://clinicaltrials.gov/study/NCT05356741"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["amx-818"],"companies":["amunix-pharmaceuticals","sanofi","merck-kgaa"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05356741","phase":"1/2","setting":"A Phase 1, Multicenter, Open-Label, First-in-Human Study of the Safety and Pharmacokinetics of VIR-5818 Alone and in Combination With Pembrolizumab in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers","sponsor":"Vir Biotechnology, Inc.","enrolled":645,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05356741/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"drug":[{"id":"amx-818","kind":"drug","name":"VIR-5818","route":"/drugs/amx-818/"}],"company":[{"id":"amunix-pharmaceuticals","kind":"company","name":"Amunix Pharmaceuticals","route":"/companies/amunix-pharmaceuticals/"},{"id":"merck-kgaa","kind":"company","name":"Merck KGaA (EMD Serono)","route":"/companies/merck-kgaa/"},{"id":"sanofi","kind":"company","name":"Sanofi","route":"/companies/sanofi/"}]}}